Jul 2026· Journal of Obstetrics and Gynaecology Canada· Vol 48, pp.
103480
· 0 citations· 8 references
Medicine
TL;DR
This paper examines how promotional language surrounding PGT-P undermines informed reproductive decision-making and argues that portraying risk as certainty misrepresents scientific evidence and may emphasize narratives of genetic optimization.
Abstract
Preimplantation Genetic Testing for Polygenic Disorders (PGT-P) emerged as a novel application of reproductive genetics. Through polygenic risk scores (PRS), proponents of PGT-P claim to predict a future child's genetic predisposition to multifactorial diseases. However, when probability is marketed as prediction, the ethical foundations of informed decision-making begin to erode. PGT-P relies on PRS to provide probabilistic information, and commercial providers frequently present these risk estimates as predictive, downplaying key limitations. This paper examines how promotional language surrounding PGT-P undermines informed reproductive decision-making and argues that portraying risk as certainty misrepresents scientific evidence and may emphasize narratives of genetic optimization.
Public views on polygenic embryo testing are examined, suggesting variability in choices across specific traits and conditions, rather than a uniform distinction between medical conditions and non-medical traits.
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