Findings support the hypothesis that chronic HIV infection may be associated with phenotypic reprogramming of CD4□ T cells rather than simple quantitative depletion alone and provide an alternative framework for investigating HIV-associated immune dysfunction.
Ageing and cytomegalovirus (CMV) infection drive major alterations to T-cell immunity. Age is also associated with an increased risk of cancers including melanoma, which is treated with T-cell modifying immune checkpoint blockade (ICB). However, the extent to which age, CMV, and treatment-induced immune changes interac...
J. M. Edwards, S. Senthi, R. Smith et al.· medRxiv· 0 citations
STING-mediated JAK-STAT suppression is identified as a novel mechanism of immune dysfunction in aging PLWH, proposing targeted STING inhibition as a potential therapeutic strategy to improve immune recovery in this vulnerable population.
Na Li, Hong-Yi Zheng, Xia Li et al.· Immunity & Ageing· 0 citations
Programmed cell death protein 1 (PD-1) is expressed by T cells during progressive multifocal leukoencephalopathy (PML), a life-threatening brain disease caused by the human-only JC polyomavirus (JCPyV). PD-1 checkpoint immunotherapy has benefited some PML patients, but reasons for its variable outcomes are unclear. Usi...
Arrienne B. Butic, E. Afanasiev, Samantha A. Spencer et al.· Nature Communications· 0 citations
