TL;DR
Findings indicate that AFF3 knockdown attenuates keratinocyte hyperproliferation and psoriasis-like inflammatory responses, at least in part, through inhibition of the MAPK signaling pathway.
Background: Periodontitis is a chronic inflammatory disease characterized by dysregulated host immune responses that drive connective tissue destruction and alveolar bone loss. Human gingival fibroblasts (HGFs) are central regulators of periodontal inflammation through their production of cytokines, chemokines, matrix-...
Background Psoriasis is a chronic inflammatory skin disease characterized by aberrant keratinocyte proliferation and dysregulated immune responses. Increasing evidence suggests that reciprocal communication between tissue-resident keratinocytes and infiltrating immune cells shapes the inflammatory microenvironment and...
A BSTRACT Psoriasis is a chronic immune-mediated skin disorder, characterized by keratinocyte hyperproliferation and inflammatory cell infiltration. The interleukin-23 (IL-23)/IL-17 axis has been established as a central driver of disease pathogenesis, and biologics targeting this pathway has significantly improv...
Introduction Psoriasis is a chronic, immune-mediated inflammatory dermatosis characterized by keratinocyte hyperproliferation and systemic metabolic comorbidities. Although proprotein convertase subtilisin/kexin type 9 (PCSK9) is a well-established regulator of lipid metabolism, its role in the cutaneous inflammatory m...
Purpose Psoriasis is a chronic inflammatory skin disease characterized by hyperproliferative keratinocytes and activated Th17/Th1 lymphocytes, which sustain a self-perpetuating cycle by releasing pro-inflammatory cytokines. The RNA-binding protein (RBP) Human Antigen R (HuR) stabilizes many of these cytokine mRNAs, con...
Psoriasis is a long-term inflammatory skin disease that occurs when a person's genes are affected by some environmental triggers. The triggers are associated with immune dysregulation by complex inflammatory mechanisms, causing the typical pathological changes in the skin. This study aimed to investigate the role of T...
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