TIDE v1.30.0 Analysis suite and derived data: Tractography-Informed Dose Estimation for Individualised TMS Intensity

Abstract

This record provides the reproducibility materials for the statistical analyses reported in the preprint “TIDE: Tractography-Informed Dose Estimation for individualised TMS intensity.” It complements TIDE v1.30.0 by providing analysis-ready derived data and standalone Python code for reproducing the manuscript-level analyses for objectives 1 and 2. The TIDE source code is archived separately. The deposit contains two independent archives. objective_1_zenodo.zip contains the behavioural-validation analyses based on 19 participants and six frontal aslant tract stimulation sites. The workflow produces dose-recommendation summaries, pooled and site-specific dose–behaviour analyses, multiple-comparison corrections, control analyses, and the manuscript figures associated with this objective. objective_2_zenodo.zip contains the multi-bundle variability analyses based on 6,492 evaluated grid poses from 27 participants and 13 target bundles. The workflow performs participant-by-bundle reduction, bundle-level variability and stimulation-efficiency summaries, boundary analyses, and data-quality checks. Each archive contains de-identified derived CSV data, Python analysis scripts, pinned software requirements, SHA-256 input checksums, software tests, and a complete README with installation and execution instructions. Subject labels use consistent numeric codes of the form sub-NN. Original subject labels and the private linkage key are not included. Running python scripts/run_all.py generates the statistical tables, text summaries, and figures in a local results directory. Python 3.11 is recommended. TIDE v1.30.0 software archive: https://doi.org/10.5281/zenodo.22019737 GitHub repository: https://github.com/marcotag93/TIDE TIDE preprint: https://doi.org/10.64898/2026.08.20.746040 The software components contained in these archives are distributed under the GNU General Public License v3.0 or later, as specified in the LICENSE file included in each archive. TIDE is research software. It is not a medical device and must not be used for diagnosis, treatment planning, or clinical decision-making.