TL;DR
A label-free Pb2+ biosensor was established based on G-quadruplex DNA (G4-DNA) and Exonuclease III (Exo III) and exhibited excellent specificity for Pb2+ and achieved satisfactory recovery rates in pond water.
Cadmium-contaminated rice poses a serious threat to public health, necessitating rapid screening methods. Unfortunately, traditional cadmium detection techniques are often cumbersome and expensive, making them unsuitable for on-site applications. In this study, we developed a graphene field-effect transistor (GFET) bio...
A novel enzyme-free and label-free fluorescent biosensor based on a cascade signal amplification strategy, integrating an entropy-driven DNA circuit (EDC) with catalytic hairpin assembly (CHA) that offers a promising platform for food safety supervision and clinical diagnostics.
Sequence-specific detection of double-stranded DNA (dsDNA) under physiological conditions remains challenging because the complementary strand is inaccessible to conventional oligonucleotide probes, often requiring thermal denaturation or protein-assisted strand separation. Here, we developed a binary DNAzyme (BiDz)...
Manganese (Mn) is an essential trace element in human body and acts as an enzyme cofactor, a neurotoxicant, and an activator of the cGAS-STING pathway. Monitoring intracellular Mn2+ is critical yet challenging due to its weak ligand-binding affinity and paramagnetic quenching effect. Here, we report a fluorescent nanop...
The strand displacement reaction (SDR) has shown considerable potential in bioanalysis due to its enzyme-free nature, predictable base-pairing behavior and excellent programmability. Herein, we developed a programmable DNA circuit with SDR-mediated target recycling-assisted DNAzyme (TRDz) for dual signal amplification,...
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