Multifunctional dual drug-loaded Gel-Alg/MINO/MEL composite hydrogel for combating three-dimensional multi-species biofilm and experimental periodontitis treatment

Curcumin-loaded chitosan thermosensitive hydrogel with sustained release for periodontal applications: an in vitro evaluation.

The curcumin-loaded chitosan thermosensitive hydrogel showed improved biological performance and sustained release when compared with free curcumin, suggesting its potential as a localized periodontal drug delivery system.

Statistical Design and Formulation of a Doxycycline-Loaded Hydrogel for Localised Periodontal Delivery Using JMP: Ex Vivo, In Vitro Antimicrobial and Safety Evaluations

Dual-Drug Chitosan Hydrogel Loaded with Metformin and Cefazolin for Antibacterial, Anti-Inflammatory and Antioxidant Treatment of Drug-Resistant Bacteria-Infected Skin Wounds

Bacterial-infected skin wounds, especially those caused by drug-resistant pathogens accompanied by persistent inflammation, remain a major clinical therapeutic challenge. Rising antimicrobial resistance compromises the therapeutic effect of conventional single-agent antibiotics, creating an urgent demand for novel woun...

Mechanical and antibacterial efficacy of minocycline- and curcumin-loaded PLGA nanoparticles coated on dental implants for the treatment of peri-implantitis

Findings indicate that PLGA-MIN/CUR coatings represent a promising multifunctional strategy for enhancing implant surface performance and preventing or managing peri-implantitis.

Sprayable NIR/pH-responsive NSC/PF127 hydrogel loaded with MoO₂, ciprofloxacin, and FGF-2 for enhanced antibacterial and pro-regenerative infected wound healing

This multifunctional, sprayable hydrogel combines targeted antibacterial action with sustained pro-regenerative signaling, offering a promising strategy for further preclinical investigations of infected wound management.

Stage-Adaptive Polymeric Platforms: Design of an Alginate/CMC Hydrogel Co-Loaded With Silver Nanoparticles and α-Pinene-Rich Essential Oil for Wound Regeneration.

Managing infected wounds requires a delicate balance between rapid antimicrobial activity and continued tissue repair. To meet this challenge, we developed a porous carboxymethyl cellulose (CMC)/alginate hydrogel loaded with Silver nanoparticles and a Pistacia atlantica essential oil rich in α-pinene. The hydrogel disp...