Protein-protein interactions as therapeutic targets in breast cancer: integrated computational and experimental advances, mechanisms and clinical translation
This review systematically summarizes the core regulatory mechanisms of PPIs in breast cancer, focusing on neomorphic interactions (neoPPIs) and hypomorphic interactions (hypoPPIs) induced by driver mutations, and dissecting their regulatory effects on key pathways such as apoptotic pathways, DNA damage repair, and hormone receptor signalling.
This review systematically summarizes the molecular mechanisms and common pathways through which PTMs contribute to therapeutic resistance in liver cancer, explores PTM-mediated mechanism underlying tumor persistence and distant recurrence, andamines how PTM-targeted strategies may reverse resistance.
Si-Min Feng, Jie Hu, Xiao-Xi Guo et al.· Frontiers in Immunology· 0 citations
Receptor-interacting protein kinase 1 (RIPK1) plays a pivotal role in regulating cell survival and death, thereby exerting complex and multifaceted functions in the initiation and progression of cancer. Its expression is frequently dysregulated across diverse malignancies and correlates strongly with poor prognosis, hi...
Jing-Yu Luo, Shu-Ya Song, Ze-Kun Li et al.· Cellular Signalling· 0 citations
This review systematically summarize the functional roles of m6A regulators, including writers, erasers, and readers, in breast cancer biology and highlights the emerging clinical potential of m6A regulators as diagnostic and prognostic biomarkers, as well as therapeutic targets for overcoming drug resistance.
Zilong Chen, Chi Zhou, Zhuo-Run Song et al.· Cancer Treatment and Researc...· 0 citations
The molecular functions of the CDK9/positive transcription elongation factor b (P-TEFb) axis, its role in super-enhancer-driven oncogenic programs, and the mechanisms by which CDK9 inhibition promotes apoptosis, epigenetic derepression, and tumor microenvironment remodeling are summarized.
Ti-Yao Liu, Zhongran Liu, Wen-Jing Wei et al.· Expert opinion on therapeuti...· 0 citations
Multidrug resistance remains a major obstacle in cancer therapy and is driven by hyperactive efflux transporters and dysregulated signaling pathways. In this study, text mining and network analyses were performed to identify key genes associated with breast cancer drug resistance. Critical regulatory nodes were ide...
Najmeh. Fattahi, C. Eslahchi, F. Ghasemi et al.· npj Systems Biology and Appl...· 0 citations
The need for integrative approaches that combine genomic insights, advanced technologies, and personalized medicine to improve breast cancer prevention and treatment is emphasized, emphasizing the need for integrative approaches that combine genomic insights, advanced technologies, and personalized medicine to improve...
