[Research status of topical insulin therapy for neurotrophic keratopathy].

Neurotrophic effects of topical insulin in persistent epithelial defects

Neurotrophic keratopathy: current concepts of the mechanisms of development and prospects for treatment

Neurotrophic keratopathy (NK), also referred to as neurotrophic keratitis, is a rare degenerative corneal disease characterized by impaired corneal sensory innervation, resulting in epithelial defects with or without stromal ulceration (melting), accompanied by reduced or absent corneal sensitivity. The most common cau...

New pharmacological and biotechnological approaches for the treatment of neurotrophic keratopathy: From growth factors to gene therapy.

This review aims to provide an integrated and pathophysiology-oriented synthesis of NK management, uniquely bridging pharmacological treatments with emerging biotechnological strategies including gene therapy, cell-based approaches, and novel drug delivery systems.

Efficacy of topical insulin as adjunctive therapy for persistent corneal erosion (an experimental study)

Objective. To investigate the possibility of using insulin as an adjunctive topical therapy for persistent epithelial defect (PED). Material and methods. The study was performed on 9 animals (18 eyes). After creating a PEC model, the clinical efficacy of topical insulin was assessed. The effect of 1 IU/ml insulin was c...

[Use of recombinant nerve growth factor in the treatment of neurotrophic keratitis associated with ichthyosis follicularis, atrichia, and photophobia (IFAP syndrome)].

The use of the drug cenegermin effectively restored the epithelium and corneal sensitivity in long-persisting corneal erosions in a child with ichthyosis follicularis, atrichia, and photophobia (IFAP syndrome), type 2.

Microemulsion Eyedrop for Delivery of a PPARα Agonist To Improve Diabetic Keratopathy Corneal Wound Healing.

Diabetic keratopathy (DK) is characterized by delayed corneal wound healing in diabetes, and recent studies have linked this defect to impaired mitochondrial respiration and reduced peroxisome proliferator-activated receptor-α (PPARα) signaling in the corneal epithelium. The PPARα agonist fenofibrate (Feno) has shown t...