Therapeutic Effects of miR-29b-Enriched Nanovesicles on Mitochondrial Injury and Neuroinflammatory Processes in Alzheimer’s Disease

miR-584-5p suppresses Aβ1-42-induced apoptosis in Alzheimer's disease cell model via targeting of HDAC1.

Icariside II protects against neuronal injury by modulating PI3K/AKT-dependent mitochondrial dynamics and apoptosis in Alzheimer’s disease models

Introduction Icariside II (ICS II), a major bioactive flavonoid metabolite from Epimedium, has been reported to exert neuroprotective effects, but its role in regulating mitochondrial dysfunction-related neuronal injury in Alzheimer’s disease (AD) has not been fully clarified. Methods In this study, we administered ICS...

Targeting neuronal injury with intranasal Arc-engineered exosomes rescues cognitive deficits in Alzheimer's disease via the mTOR-autophagy pathway.

The pathological complexity of Alzheimer's disease (AD) necessitates multifaceted therapeutic strategies. By integrating single-nucleus RNA sequencing analysis of 143,214 nuclei, this study identified excitatory neurons as the pivotal locus of cellular damage, manifesting significant dysregulation of pathways associate...

612. Astrocyte-mediated inflammatory response as a promising target for TRP: a study in humanized Alzheimer’s disease mice model

Abstract Background Chronic inflammation within the central nervous system is a defining feature of many neurological and neurodegenerative disorders, including Alzheimer’s disease (AD). Astrocytes, the most abundant glial cell population in the brain, play a pivotal role in maintaining neuronal homeostasis, synaptic s...

54. Development of therapeutics for neurodegenerative diseases via CTL1-targeted induction of M1-to-M2 microglial polarization

Abstract Background Microglia are central regulators of neuroinflammation in neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). In these conditions, pathological stimuli including lipopolysaccharide (LPS) and amyloid-β (Aβ) peptides promote a phenotypic switch from neuroprotective...

Therapeutic potential and underlying mechanisms of engineered young plasma-derived exosomes in Alzheimer's disease

The potential value of young plasma-derived EXOs in AD treatment is revealed for the first time and, through RVG engineering strategies and the elucidation of the RPTOR-autophagy mechanism, provides new insights for targeted therapy of neurodegenerative diseases.