Coevolutionary analysis-driven design of a p53 neoantigen multi-epitope peptide vaccine for lung cancer immunotherapy

Design of Multi-Epitope Cancer Vaccine Targeting p53 Tumor Antigen using Myotis lucifugus Sequencers: An Immunoinformatics Approach

Design of a novel chimeric multi-epitope vaccine construct against Staphylococcus lugdunensis using pan-genome analysis and immunoinformatics approaches

Staphylococcus lugdunensis has emerged as an increasingly important opportunistic pathogen associated with invasive infections and rising antimicrobial resistance, creating a need for new preventive approaches. In this study, a reverse-vaccinology strategy integrated with immunoinformatics analyses was applied to genom...

Designing a multi-epitope vaccine against La Crosse virus using immunoinformatics approach

La Crosse virus (LACV) is a mosquito-borne Orthobunyavirus responsible for pediatric encephalitis, with no currently approved vaccine or targeted antiviral therapy. This study aimed to design a multi-epitope subunit vaccine targeting the conserved nucleoprotein of LACV using an integrated immunoinformatics approach. Th...

Immunoinformatics-based design and in silico evaluation of a multi-epitope vaccine candidate against Naegleria fowleri.

Primary amoebic meningoencephalitis (PAM) is caused by Naegleria fowleri, a free-living amoeba. It is a fatal infection with more than 95% mortality rate. Even though several combinations of antimicrobial agents were used to treat the condition, the overall survival remains poor and no effective vaccine is currently av...

Proteome conserved multi-epitope-based vaccine construct against Nipah virus.

The study utilizes immunoinformatic-based computational methodology to design multi-epitope subunit vaccine by deciphering highly conserved antigenic epitopes across NiV strains by deciphering highly conserved antigenic epitopes across NiV strains.

Expression-Guided Immunoinformatics Design of a Recombinant Multi-Epitope Vaccine Candidate for Triple-Negative Breast Cancer Incorporating a MyD88-Derived Immunomodulatory Domain

Triple-negative breast cancer (TNBC) remains a major therapeutic challenge because of its aggressive behavior, molecular heterogeneity, and limited subtype-specific targets. This study used an integrated immunoinformatics workflow to design a recombinant tumor-associated antigen-derived multi-epitope vaccine based on M...