TL;DR
The study utilizes immunoinformatic-based computational methodology to design multi-epitope subunit vaccine by deciphering highly conserved antigenic epitopes across NiV strains by deciphering highly conserved antigenic epitopes across NiV strains.
Dengue virus (DENV) and chikungunya virus (CHIKV) co-infection poses a growing challenge in regions where both arboviruses co-circulate, highlighting the need for integrated vaccine strategies. Here, we designed a multi-epitope subunit vaccine candidate targeting conserved regions of the DENV NS1 protein and the CHIKV...
Rift Valley fever virus (RVFV) is a major zoonotic pathogen causing significant outbreaks in humans and livestock, with no licensed effective vaccines currently available. This study employed reverse vaccinology and immunoinformatics approaches to design three multi-epitope mRNA vaccine candidates against RVFV. Conserv...
Usutu virus is an emerging mosquito-borne flavivirus with an expanding geographic distribution and increasing public health relevance, yet no licensed vaccine is currently available. This study used an integrated reverse vaccinology strategy to identify conserved immunogenic regions from the Envelope protein and NS5 pr...
The proposed multi-epitope vaccine shows promising immunological and structural properties, supporting its potential against S. typhimurium, pending experimental validation.
A computationally validated multi-epitope peptide vaccine construct with strong immunogenicity were generated, but validation through the in-vitro and in-vivo study of the developed vaccine is essential to assess its efficacy and immunogenicity profile.
NDVaxWA is a potential vaccine candidate for improved protective efficacy against the currently circulating NDV strains in West Africa and an in silico immune simulation revealed robust humoral and cell mediated responses following vaccination with NDVaxWA.
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