A highly conserved BECN1 domain located between previously characterized BH3 and coiled-coil domains is delineated and its structure and role in autophagy is elucidated.
Human NHE6 (HsNHE6) is an endosomal Na⁺/H⁺ exchanger essential for maintaining luminal pH and endo-lysosomal trafficking in neurons. HsNHE6 mutations are implicated in devastating neurological syndromes, but mechanistically the transporter remains poorly understood. Here, we present the single-particle cryo-electron mi...
L. P. Feilen, Lara Sach, Emil E. Tranchant et al.· Nature Communications· 0 citations
Phosphorylation of intrinsically disordered regions (IDRs) is widely viewed as a mechanism for encoding regulatory information through structural transitions, as exemplified by the RNA polymerase II C-terminal domain (CTD), where phosphorylation induces local conformational changes such as proline isomerization. Howeve...
Rong Hu, E. Usher, Olivia A Fraser et al.· Journal of Physical Chemistr...· 0 citations
The Keap1-Nrf2 system plays a central role in cellular defense against oxidative stress. Structural information on full-length Keap1 is essential for understanding the molecular basis of this regulation. However, its overall architecture has remained elusive due to pronounced conformational flexibility. In this study,...
Ritsumi Saito, Takeshi Kawabata, S. Yamashita et al.· Redox Biology· 0 citations
FOXM1 is a cell proliferation-driving transcription factor activated by phosphorylation-induced conformational changes. In its inactive state, an intramolecular β-hairpin within the transactivation domain (TAD) binds the N-terminal repressor domain (NRD), forming a composite β-sheet that locks the protein in an autoinh...
Sara AlRawashdeh, Raghd Obidat, Aylin del Moral-Morales et al.· Journal of Chemical Informat...· 0 citations
Macroautophagy is a conserved catabolic process that facilitates the degradation of cellular material by capturing it in double membrane vesicles termed autophagosomes. In Saccharomyces cerevisiae, selective macroautophagy is initiated by the scaffolding protein Atg11. Atg11 recruits the transmembrane protein Atg9, whi...
Sarah I Najera, Devika Andhare, Anna E. Hill et al.· bioRxiv· 0 citations
It is shown that DM3 reversibly assembles into higher-order filaments in a salt-sensitive manner, which reveals how structural plasticity in protein assemblies enables a single protein to coordinate multiple stress-response functions, highlighting a general mechanism for regulating protein activity in plants.
Nayun Kim, Wei-Lin Wan, Yi-Yun Tan et al.· bioRxiv· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.