Aug 2026· Cancers· Vol 18, pp. 2786· 0 citations· 33 references
Medicine
TL;DR
The connection between mitoxyperilysis, Annexin A1, and macrophages may help explain immune escape in liver cancer and may guide future biomarker and treatment research.
Abstract
Simple Summary Primary liver cancer remains difficult to treat because tumor cells can reshape their surroundings and weaken immune responses. This study examined mitoxyperilysis, a newly described form of cell death, to determine whether it contributes to this immune suppression. By analyzing patient gene-expression data and testing liver cancer cells in laboratory and mouse models, we found that tumors with stronger mitoxyperilysis-related signals contained more tumor-supporting macrophages and were linked to poorer outcomes. The cancer cells also released more Annexin A1, which promoted macrophages toward an immune-suppressive state, while reducing Annexin A1 weakened this effect and slowed tumor growth. These findings suggest that the connection between mitoxyperilysis, Annexin A1, and macrophages may help explain immune escape in liver cancer and may guide future biomarker and treatment research.
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