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Edge-centric brain connectomes reveal two molecularly distinct neurobiological subtypes of adolescent major depressive disorder.

Yingbo Shao Bao-Lin Wu Xun Zhang Qian Zhang Baoshuai Zhang Kun Xu Li-Na Jiang Neil Roberts Zhi-Yun Jia
Aug 2026 · European Child and Adolescent Psychiatry · 0 citations · 35 references
Medicine

TL;DR

This study investigated the neural and molecular bases of individual differences in adolescent MDD patients by integrating a novel edge-centric brain connectome with transcriptomic and neurotransmitter profiles, and identified two robust adolescent MDD subtypes.

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