SERCA2 gatekeeper role in aortic autophagy: targeting the Ca2+-mTOR axis to prevent aortic dissection.

ACAN regulates VSMC mitochondrial homeostasis through the YAP1/TAZ pathway and contributes to the onset and progression of aortic dissection

REDD1 Silencing Aggravates Aortic Dissection and Promotes VSMC Apoptosis with Autophagy-Related Changes

Background: Aortic dissection (AD) is a life-threatening vascular disease with high mortality, yet its molecular pathogenesis remains incompletely understood. This study investigated the role of regulated in development and DNA damage responses 1 (REDD1) in vascular smooth muscle cells (VSMCs) apoptosis and the underly...

SREBF2 promotes mitophagy and protects against ferroptosis via Cav-1-regulated PINK1/Parkin signaling in ischemic heart failure

Results demonstrate that SREBF2 mitigates MI-induced HF by activating the Cav-1/PINK1/Parkin axis to promote mitophagy and inhibit ferroptosis, and identify SREBF2 as a promising therapeutic target in heart failure.

AKT1-dependent phosphorylation of PRMT5 prevents Siah1a-mediated CtBP1/2 ubiquitination to contribute to abdominal aortic aneurysm progression.

AIMS Abdominal aortic aneurysm (AAA) is a progressive vascular disease characterized by chronic inflammation and extracellular matrix (ECM) degradation. Although C-terminal binding protein 1 and 2 (CtBP1/2)-mediated transcriptional activation has been implicated in AAA progression, the upstream mechanisms regulating Ct...

Notoginsenoside R1 attenuates post-ischemic pyroptosis: a novel CKLF1-endoplasmic reticulum stress pathway-mediated mechanism.

BACKGROUND Ischemic stroke induces neuronal pyroptosis driven by excessive endoplasmic reticulum (ER) stress, which exacerbates secondary brain injury. Notoginsenoside R1 (NGR1) has demonstrated neuroprotective properties; however, whether its mechanism involves the modulation of chemokine-like factor 1 (CKLF1)-mediate...

Sirt1 attenuates calcific aortic valve disease by inhibiting ferroptosis and enhancing mitochondrial function via the activation of the Nrf2/HO-1/FTH1 axis

Calcific aortic valve disease (CAVD) is a progressive disorder characterized by valvular calcification and currently lacks effective pharmacological therapies. Sirtuin 1 (Sirt1) has emerged as a cardioprotective factor; however, its role in CAVD remains unclear. The present study aimed to investigate whether Sirt1 atte...