Multi-class UHPLC-MS/MS method for the simultaneous determination of 32 endocrine-disrupting chemicals in the urine of pregnant women.

Target quantification and ion mobility-HRMS suspect screening of BPA and its alternatives in human urine.

Bisphenol A (BPA) and its structural alternatives are contaminants of concern due to their endocrine-disrupting properties and widespread human exposure. The progressive replacement of BPA by alternative bisphenols has increased the need for sensitive analytical methods capable of monitoring both regulated and emerging...

Development and Validation of a UHPLC–MS/MS Method for Trace-Level Determination of N-Nitroso Chlordiazepoxide in Chlordiazepoxide Hydrochloride Capsule Dosage Form

One-step SPE-UHPLC-MS/MS for simultaneous detection of fenbendazole and metabolites in animal-derived foods.

Fenbendazole (FBZ) is a highly effective antiparasitic agent widely used in veterinary medicine; however, its improper application can lead to residues in edible animal-derived products, posing potential health risks to humans through accumulation via the food chain. This study aimed to establish an ultra-high-performa...

Biomonitoring: a demonstration of the importance of direct analytical methods for the assessment of chemical exposures

Introduction Biomonitoring of commercial endocrine-disrupting chemicals (EDCs) increasingly underpins exposure assessment and risk evaluation, yet most large-scale studies still rely on indirect, enzymatic hydrolysis–based methods whose quantitative performance has not been systematically verified. Here, we describe th...

Assessment of Environmental Phenolic Endocrine-Disrupting Chemicals in Human Urine and Their Association with Demographic, Lifestyle, and Metabolic Factors in a Bangladeshi Population Using High-Throughput Solid-Phase Extraction Coupled with UHPLC–Tandem Mass Spectrometry

Background: Environmental phenolic endocrine-disrupting chemicals (EDCs) are widely distributed contaminants associated with plastics, food-packaging materials, thermal papers, flame-retardant products, antimicrobial formulations, and a variety of household and personal-care products. Human exposure to these compounds...

Validation of an integrated analytical method for the simultaneous quantification of 12 PFAS in drinking water, plant-based milk alternatives and skimmed milk.

Per- and polyfluoroalkyl substances (PFAS) are persistent contaminants that may threaten food safety. Standardized analytical methods for low-fat liquid foods remain limited. This study validates a novel integrated workflow for the simultaneous determination of 12 PFAS in drinking water, plant-based milk alternatives a...