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An alignment-last approach enables rapid transcriptomic biomarker discovery in large cohorts

Erkan Narmanli Alexandre Lanau Mara Neacsu Mariia K. Koshkina Pierre Fumeron Philippe Martin N. Servant Nicolas Perrin-Gilbert Joshua J. Waterfall
Sep 2026 · bioRxiv · 0 citations · 98 references
Biology

TL;DR

Unsupervised read-level differential analysis recovers established lncRNA biomarkers; uncovers new prognostic transposable-element reads in adrenocortical carcinoma and sarcomas; and extracts signals even from reads that fail to align.

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