Aug 2026· microPublication Biology· Vol 2026· 0 citations· 8 references
Medicine
TL;DR
It is found that reproductively aged wild-type worms and wrt-10 ( aus36 ) null mutants both had a greater likelihood of progeny production after 24-h or 48-h fasting periods in early adulthood, indicating that wrt-10 is not required for this response, and wrt-10 may enable diet-restricted C. elegans adults to channel resources towards their progeny.
Abstract
Low food availability can cause delays in reproductive aging to allow for eventual improvements in conditions, or might promote investment in offspring to increase their survival. Here, we tested whether Caenorhabditis elegans Hedgehog-related wrt-10 mediates these responses. We found that reproductively aged wild-type worms and wrt-10 ( aus36 ) null mutants both had a greater likelihood of progeny production after 24-h or 48-h fasting periods in early adulthood, indicating that wrt-10 is not required for this response. However, unlike wild-type, wrt-10 ( aus36 ) mutants did not produce longer larvae after fasting. Therefore, wrt-10 may enable diet-restricted C. elegans adults to channel resources towards their progeny.
It is shown that ubiquitous degradation of DAF-2 in male C. elegans increases median lifespan by more than 440%, one of the longest lifespan extensions by a single intervention to date.
Rose S. Al-Saadi, Hannah B. Lewack, Patrick C. Phillips· Aging· 0 citations
Simple Summary Short-term high temperature is an important environmental factor affecting the population dynamics of invasive insect pests. Kr-h1 is a key gene involved in insect reproduction and development. Here, we investigated the role of ZcKr-h1 in female melon flies under normal and short-term heat conditions. We...
The Caenorhabditis Intervention Testing Program recently characterized the longevity-promoting effects of all-trans-retinoic acid (atRA) in C. elegans . While we observed that atRA extended lifespan across multiple genetic backgrounds, environmental factors may influence its efficacy. One such factor is 5-Fluoro-2'-deo...
Stephen A. Banse, Anna L. Coleman-Hulbert, Christine A. Sedore et al.· microPublication Biology· 0 citations
Organismal homeostasis relies on balancing cellular metabolic decisions with environmental conditions, especially during reproduction. Using Caenorhabditis elegans, we tested whether vitellogenesis, or the deposition of lipid-rich yolk into oocytes, is required for reproductive output and metabolic balance by creating...
Monica M. Macharios, Yasmine D. Hernandez, Peter C. Breen et al.· microPublication Biology· 3 citations
Nearly a century ago, restricting diet during early-life periods was suggested to extend lifespan in rats and in Daphnia1,2. The effect of juvenile diet on adult physiology and lifespan has subsequently been described in other model organisms, including fruit flies3, 4–5 and mice6, 7–8; however, its mechanism remains p...
Hina Kosakamoto, Rina Okada, Clive S. Barker et al.· Nature· 2 citations
