UCOE-Mediated Transcriptional Stabilization Combined with EGFP-Based FACS Screening Enables Efficient Selection of High-Producing CHO Cells.

Reyhane Lohrasbi Abbas Daneshipour Seyedeh Hoda Jazayeri Zahra Halfinezhad Masoumeh Azimi Baharak Abd Emami A. Dalman Mohsen Gharanfoli A. Amiri-Yekta

Aug 2026 · Molecular Biotechnology · 0 citations · 34 references

Medicine

TL;DR

This study demonstrated that UCOE-mediated transcriptional stabilization establishes a robust expression framework while EGFP-based FACS screening enables efficient enrichment of high-producing cells and enhances protein yield with potential for further optimization in larger-scale applications.

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