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Transforming clinical apheresis waste into a renewable source of patient-derived CD34+ hematopoietic stem cell biobank for beta-hemoglobinopathy research and therapeutic discovery

Jun Liu Shin-young Park Hirotomo Nakahara Yembur Ahmad Ziyang Shen Suhayla Sarhan S. Ferrara Vanessa Anjurthe Kristi Georgilas Sarah Nikiforow Zankar Desai Shang-Chuen Wu Ryan Jajosky Sarthak Saha Nelya Christiansen Kendra Munkacsy Jiajia Li Hong-Bo R. Luo Sophia Adamia S. Stowell A. Mishra Li Chai
Aug 2026 · bioRxiv · 0 citations · 6 references
Biology

TL;DR

Clinical apheresis waste is used to generate a single-center biobank of high-quality, research-grade CD34+ HSPCs from patients with sickle cell disease and beta-thalassemia, addressing a recognized gap in the hemoglobinopathy pipeline.

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