Postbiotics as a therapeutic frontier in Parkinson’s disease: Insights into molecular pathways and neuroprotective effects

Postbiotics as a Therapeutic Target in Cognitive Impairment: Exploring into Molecular Pathways and Neuroprotective Effects.

A systematic evaluation of the role of postbiotics in the prevention and management of CI across different neurological and metabolic disorders is provided, and the available preclinical findings with potential therapeutic implications and future directions are summarized.

Therapeutic potential of apigenin in neurodegenerative diseases and brain health

Hesperidin as a Neuroprotective Agent in Parkinson’s Disease: Mechanistic Insights and In Silico Validation

Combined in silico and experimental findings highlight hesperidin’s strong binding to key molecular targets, whereas experimental evidence also confirms its antioxidant, anti-inflammatory, and anti-apoptotic effects, supporting its potential as a disease-modifying candidate in PD therapy.

The Gut-Brain Axis: Exploring the Role of Gut Microbiota in Alzheimer's Disease Pathogenesis and Therapeutics.

INTRODUCTION Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-β (Aβ) accumulation, tau hyperphosphorylation, and cognitive decline. Increasing evidence implicates the gut-brain axis as a key regulator of AD pathogenesis through immune, metabolic, and neuroendocrine pathways....

Neuroprotective or Destructive? A Comprehensive Review on Plant Peptides for Neurodegenerative Disease

Progressive neuronal death caused by oxidative stress, aberrant protein aggregation, cholinergic deficits, neuroinflammation, and dysbiosis of the gut‐brain axis are attributes of neurodegenerative disorders (NDs), which include Alzheimer's and Parkinson's diseases. The investigation of novel Phyto therapeutics is prom...

Intestinal microbiota in neurodegeneration and ageing: Mechanisms, pathways, and therapeutic interventions.

This chapter summarizes current knowledge of the microbiota-gut-brain axis (MGBA) and elucidates how intestinal microbes and their metabolites communicate with the central nervous system via neural, immune, endocrine, and metabolic pathways.