rs57494551 increases CXCR5 expression and IgM+ CXCR5+ B-cell infiltration in the portal area of primary biliary cholangitis.

Hitomi Yuki Yoshihiro Aiba Kazuko Ueno Haruka Takahashi M. Kono Kazuhiro Sugi Yuji Teraoka S. Takaki A. Naganuma Motoyuki Kojima N. Nishida Y. Kawai Minae Kawashima Seik-Soon Khor M. Yasunami A. Komori Shinji Shimoda K. Ishigaki M. Nagasaki K. Tokunaga Minoru Nakamura

Aug 2026 · Journal of gastroenterology · 0 citations · 55 references

Medicine

TL;DR

Immune dysregulation and portal inflammation are affected by increased expression of CXCR5 on IgM+ B-cells in PBC patients who have the risk allele of rs57494551, indicating that CXCR5 is a potential therapeutic target for PBC.

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