Genetically Customized Generations—A Need for Increased Genetically Customized Generations—A Need for Increased Regulatory Control over Gene Editing Technology in the United Regulatory Control over Gene Editing Technology in the United States States

Virus-induced Genome Editing in Plants: Viral Vector Biology, Germline Access and the Evidence Base for Heritable, Transgene-Free Crop Improvement

A critical review evaluates the strength and limits of the evidence for the claim that virus-derived products are transgene-free, and prioritised research directions are proposed, emphasising standardised reporting of progeny-level outcomes, biocontained vector design, and genotype-spanning validation in elite crop bac...

CRISPR–Cas9 genome editing: technological advances, delivery strategies and precision engineering of primary cells for therapeutic application in genetic disorders and diabetes mellitus

Recent advances in CRISPR-Cas9–mediated genome editing are highlighted, emphasizing breakthroughs in primary cell editing and the development of translational models for genetic diseases and diabetes mellitus.

Programmable enzymes for targeted gene insertion.

Generation of Genetically Engineered Embryos Using Gene Editing and Somatic Cell Nuclear Transfer for Production of Sheep Models of Human Disease.

Large animal models are valuable tools for investigating human disease. Sheep, pigs, and goats often better recapitulate the anatomy and physiology of human organs and the complexity of human disease, thereby enhancing their clinical relevance compared to rodents. CRISPR-Cas9 and somatic cell nuclear transfer (SCNT) en...

Programmable large-DNA writing in the human genome.

Recent advances in programmable large-DNA writing in the human genome are reviewed across four mechanistic categories: recombinase-, prime editing-, transposase-, and retrotransposon-mediated technologies.

CRISPR-Based Gene Editing in Human and Animal Health: Revolutionizing Disease Resistance and Treatment

This study explores the diverse applications of CRISPR, highlighting its role in treating genetic disorders such as sickle cell anemia and Duchenne muscular dystrophy, advancing cancer immunotherapies, and developing CRISPR-based antiviral therapies for HIV and COVID-19.