A Poly(rC)-Binding Protein Mediates Iron Delivery to Ferritin in Anopheles stephensi

Chiging Tupe Bharti Goyal Tanwee Das De Durva Bhatt B. Dixit Kailash C. Pandey Byoung-Kuk Na S. Emami S. Chakraborti

Aug 2026 · bioRxiv · 0 citations · 48 references

Biology

TL;DR

Functional analyses demonstrated that KH2-KH3 linker and KH3 domain of PCBP, plays an important role in the AsPCBP-ferritin interaction and that deletion of these regions, unexpectedly increased ferritin binding affinity but impaired iron delivery, indicating that these regions are dispensable for complex formation but essential for efficient iron transfer.

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