Review

Conserved copper(I)-binding auxiliary domains link virulence-associated LPMOs to copper homeostasis in the intestinal environment

Eirik G. Kommedal Hanne Berggreen Synnøve Elisa Rønnekleiv Henrik Vinther Sørensen Ane Runningen Yong Zhou Ute Krengel Å. Røhr V. Eijsink Zarah Forsberg

Aug 2026 · bioRxiv · 0 citations · 89 references

Biology

TL;DR

It is demonstrated that these multidomain LPMOs from food-borne intestinal disease-causing Gram-positive bacteria from the genera Bacillus and Listeria contain conserved, yet structurally distinct copper(I)-binding motifs on their non-catalytic third domain.

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