WGCNA-based identification and experimental validation of TOP2A as a key regulator of ferroptosis in sepsis-associated acute respiratory distress syndrome
The transcriptional regulation of topoisomerase II alpha (TOP2A) by GATA binding protein 2 (GATA2) was verified using JASPAR prediction, chromatin immunoprecipitation (ChIP), and dual-luciferase reporter assays.
Sepsis-induced acute lung injury (ALI) remains a devastating complication of sepsis, marked by uncontrolled pulmonary inflammation, alveolar-capillary barrier disruption, and high mortality. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, is implicated in sepsis-related org...
Jin Li, Ya-Zhou Li, Chun-Tao Song et al.· Frontiers in Immunology· 0 citations
Objective Sepsis is a life-threatening condition with high mortality and complex pathology. Early diagnosis is critical but remains challenging due to a lack of effective biomarkers. This study aims to identify specific diagnostic markers to distinguish sepsis from non-sepsis, and to develop a robust diagnostic model....
Zhi-Wen Gong, Xin-Yi Liu, Xiao-Yun Xiang et al.· Frontiers in Immunology· 0 citations
Functional enrichment analyses revealed that these FRDEGs are primarily associated with ferroptosis, hypoxia response and immune inflammation, and these FRDEGs are primarily associated with ferroptosis, hypoxia response and immune inflammation.
Ying Tan, Zihui Liu, Siyuan Song et al.· Experimental and Therapeutic...· 0 citations
NETs-related genes GSTM1, SDC1, and VTN are identified as novel biomarkers for AP and semaxanib may have potential associations with pathways related to GSTM1, SDC1 and VTN, thereby participating to some extent in the intervention of acute pancreatitis.
Huang Chen, Ping-Ting Huang, Zu-Wei Wang et al.· International Immunopharmaco...· 0 citations
Infection-associated acute respiratory distress syndrome (ARDS) is a common and severe clinical disease in critical care medicine, with high mortality and a significant burden on intensive care resources. Current treatments mainly rely on supportive care, and there is still a lack of effective targeted drugs and diagno...
Xiao-Yan Li, Ting-Ting Liu, Yidan Zhang et al.· SAGE Open Medicine· 0 citations
Sepsis is a life-threatening syndrome caused by a dysregulated host response to infection and remains a major cause of mortality in critically ill patients. Multiple forms of programmed cell death (PCD) may contribute to immune dysregulation and organ injury, but their transcriptional patterns across disease severi...
Jing Xu, Peng Wang, Ming-Zhao Xu· Frontiers in Cell and Develo...· 0 citations
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