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MICAL2 as a key effector of β-catenin signaling driving melanoma progression and therapeutic resistance.

P. Sohier J. Raymond Zackie Aktary N. Zidi Lara Araktingi N. Charoenchon Céline Pisibon Sylvie Caberia É. Pasmant Nicolas Macagno V. Delmas C. Gaudy-Marqueste E. Steingrímsson R. Ballotti Valérie Petit L. Larue
Aug 2026 · Cell Death and Differentiation · 0 citations · 56 references
Medicine

TL;DR

It is demonstrated that activation of β-catenin is associated with a poor prognosis in melanoma and inhibiting the enzymatic activity of MICAL2 offers a promising and innovative strategy to improve outcomes in β-catenin-driven melanoma.

DOI PubMed Semantic Scholar
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