RNA Structure and Its Function.

The RNA structural code: orchestrating gene expression and enabling precision therapies.

Computational modeling of an RNA-peptide world

Emergence and evolution of functional RNA and protein structures are the central problems for understanding the origin of life. Although it is well known that catalytically active RNA elements, ribozymes, can catalyze many reactions 1–3, including peptide bond formation, the specifics of the transition from the hypothe...

RNA engineering approaches to aid high-resolution structure determination of medium- to large-sized RNAs.

High-resolution structure determination of RNA remains a major challenge due to its conformational flexibility, intrinsic heterogeneity, and susceptibility to degradation. Although RNA plays central roles in gene regulation, viral replication, and cellular homeostasis, RNA-only structures represent a small fraction of...

In silico designing of small molecules for targeting RNA: current landscape and future directions

Characterization of RNA Structure Dynamics with Trans-Factors Using Single-Molecule Optical Tweezers.

From RNA design to delivery: Computational strategies for functional RNA therapeutics

RNA therapeutics provide a revolutionary means of treating a variety of diseases by precisely regulating gene expression and protein synthesis, with great medical significance. However, there are three key challenges to its clinical application: the inherent instability of RNA, the need for controlled regulation of RNA...