TL;DR
The HVC nucleus of the zebra finch song motor circuit demonstrates an ability to restore the original birdsong after lesioning, even though neurons participate stochastically in song generation, and the unreliable participation of neurons may provide a flexible manifold for both learning and recovery.
The ability to switch between tasks is a core component of human intelligence, yet a mechanistic understanding of this capacity has remained elusive. Long-standing debates over how task switching is influenced by preparation for upcoming tasks or interference from previous tasks have been difficult to resolve without q...
Previous work suggests that different groups of neurons in orbitofrontal cortex (OFC) constitute the building blocks of a circuit in which economic decisions are formed. Here we used network inference analysis (Ising model) to shed light on the internal organization of this circuit. We examined populations of neurons r...
Cortical circuits must respond flexibly to new inputs while integrating information about the past, yet the way in which neural activity reconciles these competing demands remains unclear. Combining Neuropixels recordings from six mouse visual areas with mechanistic circuit modeling, we identify a dynamical regime in w...
Excitatory (E) and inhibitory (I) neural populations interact within and across distributed regions to support brain function, yet local and distributed E and I dynamics during naturalistic behavior remain unknown. To address this gap, we developed a dual-color multisite spectrally- resolved fiber photometry platform t...
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