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The data indicate that IRAK-M impairs host defense during pneumonia caused by two common respiratory pathogens, including Klebsiella pneumonia and Streptococcus pneumonia.
It is shown here that CD44 facilitates bacterial outgrowth and dissemination during pneumococcal pneumonia, which in lethal infection results in a prolonged survival of CD44 KO mice, and during sublethal pneumonia CD44 contributes to the resolution of the inflammatory response.
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