TL;DR
The data indicate that IRAK-M impairs host defense during pneumonia caused by two common respiratory pathogens, including Klebsiella pneumonia and Streptococcus pneumonia.
Pneumonia continues to represent a significant global health concern, characterized by substantial morbidity and mortality despite advancements in modern medicine. This respiratory infection remains a leading cause of hospitalization and death worldwide, particularly in developing nations. This study inves...
IL-6 and MIP-2 played a role in PLY-induced PMN recruitment considering that this response was partially diminished in IL-66 gene deficient mice (P = 0.1 vs. wild type mice), and in mice treated with anti-MIP-2 antiserumm (P<0.05).
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disorder that affects up to 12% of the general population. It is associated with significant morbidity and a considerable burden on the healthcare system. Tumor necrosis factor -induced protein 8-like 2 (TIPE2) is an immune-related protein...
ABSTRACT Enterovirus 71 (EV-A71) can cause inflammatory injury beyond the central nervous system, yet the host pathways driving EV-A71-associated skeletal muscle pathology remain poorly defined. Toll-like receptor 2 (TLR2) is a key innate immune sensor capable of amplifying inflammatory signaling during infection. Here...
Streptococcus pneumoniae (Spn) produces substantial amounts of hydrogen peroxide (H₂O₂), a metabolic byproduct with cytotoxic and immunomodulatory effects. Although pneumococcal H₂O₂ has been implicated in pathogenesis, its contribution to pulmonary immune responses and epithelial transcriptional responses dur...
Fungal infections cause substantial morbidity and mortality, particularly in immunocompromised individuals, yet the immune mechanisms that distinguish protective inflammation from tissue-damaging responses remain incompletely understood. Monocyte chemoattractant protein-1, also known as C-C motif chemokine ligand 2 (MC...
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