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Author

Barak Rotblat

3 papers indexed here

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#protein folding Open access Oct 2026

The mitochondrial chaperone HSPD1 folds MTHFD2 independently of its co-chaperone HSPE1

Acquiring new cellular states entails metabolic reprogramming driven by changes in the expression of cytosolic and mitochondrial metabolic enzymes. Most mitochondrial proteins are synthesized in the cytosol and imported into the mitochondria in a linear form, after which they are folded by a network of mitochondrial ch...

Shani Gabbay, Hila Ben-David, Shatha S. Alassam et al. · 0 citations
#gene editing Open access Sep 2026

Defending synthetic DNA orders against intra-order splitting-based obfuscation

Biosecurity screening of synthetic DNA orders is a key defense against malicious actors and careless enthusiasts producing dangerous pathogens or toxins. It is important to evaluate biosecurity screening tools for potential vulnerabilities and to work responsibly with providers to ensure that vulnerabilities can be pat...

Shaked Tayouri, Vladislav Kogan, Jacob Beal et al. · 0 citations
#protein folding Open access Sep 2026

HSPD1 promotes neuroblastoma by augmenting MYCN expression

It is shown that HSPD1 depletion in MYCN-amplified NB cells led to reduced mitochondrial translation, MYCN expression, and tumorigenesis in vitro and in vivo and establishes HSPD1 as a promising target for the treatment of MYCN-amplified NB.

Shatha S. Alassam, Dinesh Babu Manikandan, Hila Ben-David et al. · 0 citations

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