Comparing YAPWW1 and TAZWW: Similar Binding Sites but Different Stability and Conformational Dynamics
High resolution LATS2:YAPWW1 crystal structure and molecular dynamics simulations suggest that preorganized peptides bind more tightly and less selectively, while flexible peptides incur larger binding penalties that dynamic YAPWW1 compensate more effectively.
Claire Merlen, Yannick Mesrouze, Suzanne Chau et al.
· Biomolecules · 0 citations