The gradual expansion and folding of the cortex are key factors in human cognitive evolution, yet their molecular underpinnings remain not well understood. Here we identify cyclin B1 interacting protein 1 (CCNB1IP1) gene as a key regulator of human brain evolution using tree shrew as an outgroup. In primates, CCNB1IP1...
Ting Hu, Peng-Cheng Ma, Yi-Fan Kong et al.· Nature Genetics· 0 citations
A homozygous mutation in
RNF220
, encoding a RING-type E3 ubiquitin ligase, is associated with male infertility featuring small-headed sperm, but the precise roles and mechanisms of
RNF220
in spermatogenesis remain elusive. Here, we explored the function of
RNF220
in spermatogenesis using a Stra8-Cre-mediated...
Jing-Mei Cha, Huijuan Lin, Yingqian Xia et al.· Cell Death & Disease· 0 citations
ABSTRACT In the central nervous system, oligodendrocytes (OLs) generate myelin sheaths to support rapid nerve impulse conduction. OL lineage cells, especially oligodendrocyte precursor cells (OPCs), feature high metabolic activity and are exposed to severe oxidative stress, but the protective mechanisms remain poorly u...
Yuwei Li, Haijun Zhang, Jieya Zhou et al.· Advancement of science· 0 citations
In vivo evidence is provided supporting a model in which DJ-1 deficiency can promote key PD-like phenotypes in tree shrews, potentially involving PSer129αSyn accumulation, nigral dopaminergic neuron loss, and motor dysfunction.
Hao Li, Leyi Mei, Jing-Mei Cha et al.· Cell Death & Disease· 0 citations
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