State-selective inhibition of alpha-synuclein aggregation by de novo oligomer-binding proteins
Deep learning-based protein design is used to generate de novo binders capturing this region of α-synuclein in a β-strand conformation to establish a set of molecules that target distinct aggregation intermediates and mechanistically reshape αSyn assembly.
Yun-Xuan Zhang, Hannah L. Han, L. Ortigosa-Pascual et al.
· bioRxiv · 0 citations