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Cryo-electron microscopy reveals a conserved role for RPL41 in maintaining ribosome dynamics and translational fidelity, indicating that RPL41 supports ribosome function and long-protein homeostasis in mammals.
It is shown that PBR1 operates at the endoplasmic reticulum to support the folding and stability of Fks1, enabling proper cell-wall assembly and reveals an ER quality-control mechanism that enables constrained membrane proteins to fold efficiently and perform essential cellular functions.
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