Author

Evan T. Powers

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Open access Oct 2026

Rank Normalization Enables Cross Pathway Comparison in Degradation Resolved Proteome Turnover Analysis

Protein homeostasis, or proteostasis, is essential for cellular health, and its disruption contributes to cancer, aging, and neurodegenerative disease. Proteostasis is maintained largely by two intracellular degradation systems: the ubiquitin proteasome system (UPS) and the autophagy lysosomal pathway (ALP). Here, we c...

Zi Gao, Qiang Xiao, Jeffery W. Kelly et al. · bioRxiv · 0 citations

#protein folding Review Oct 2026

Survey of the human proteostasis network: translation, protein folding, and organelle-specific systems.

The human proteostasis network is operationally defined by providing a comprehensive, annotated, and manually curated list of its components classified into nine Branches based on their function and localization - cytonuclear proteostasis, ER proteostasis, mitochondrial proteostasis, nuclear proteostasis, proteostasis...

Evan T. Powers, Suzanne Elsasser, T. Stoeger et al. · Autophagy · 0 citations

#protein folding Review Open access Oct 2026

Survey of the human proteostasis network: the autophagy-lysosome pathway.

The condition of having a healthy, functional proteome is known as protein homeostasis, or proteostasis. Establishing and maintaining proteostasis is the province of the proteostasis network, a highly interconnected system of over 3000 components that regulate protein synthesis, folding, localization, and degradation....

Evan T. Powers, Suzanne Elsasser, Ee Phie Tan et al. · Autophagy · 1 citation