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#protein folding Review

Survey of the human proteostasis network: translation, protein folding, and organelle-specific systems.

Evan T. Powers Suzanne Elsasser T. Stoeger Ke-Di Cao M. Collier T. Rainbolt Saugat Pokhrel Shuhei Taguwa Xiao-Jing Sui Roy D. Kurtzbard Patricia Martínez-Botía Reese A. K. Richardson Ching-Chieh Chou Ranen Aviner Natália Barbosa Vincent B. Masto Fábian Morales-Polanco Leandro Lima Alejandro Rodriguez Gama Eric Mockler D. Garza Jeffery W. Kelly Daniel Finley Eugenia M. Clerico Miguel A. Prado J. Gestwicki L. Elia S. Finkbeiner Judith Frydman Richard I. Morimoto
Oct 2026 · Autophagy · pp. 1-15 · 0 citations
Medicine

TL;DR

The human proteostasis network is operationally defined by providing a comprehensive, annotated, and manually curated list of its components classified into nine Branches based on their function and localization - cytonuclear proteostasis, ER proteostasis, mitochondrial proteostasis, nuclear proteostasis, proteostasis network regulation, translation, extracellular proteostasis, and the autophagy-lysosome pathway.

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