Author

Feixiong Cheng

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#gene editing Open access Oct 2026

Alzheimer’s disease target and drug discovery by leveraging multiomics and electronic health data

Despite prolific genomic data from individuals with Alzheimer’s disease (AD), translation into treatments has lagged. Here we applied Mendelian randomization to multiple AD genome-wide association studies and functional multiomics datasets to nominate druggable targets, identifying 19 targets for individuals of Europea...

Yuan Hou, Yichen Li, Pengyue Zhang et al. · Nature Neuroscience · 0 citations

#gene editing Open access Oct 2026

Interferon-induced OASL restricts ADAR1 p150 RNA binding and A-to-I RNA editing

The interferon (IFN)-inducible RNA editor ADAR1 p150 catalyzes adenosine-to-inosine (A-to-I) editing of host and viral double-stranded RNAs, limiting aberrant innate immune sensing and regulating gene expression. How ADAR1 p150 activity is regulated during host–virus interactions remains poorly understood. Here, we ide...

Stephanie Leon Quinonez, A. Gupta, Soowon Kang et al. · bioRxiv · 0 citations

#protein folding Open access Sep 2026

Catechol-O-methyltransferase connects dopamine homeostasis to redox signaling, metal homeostasis, and protein folding in schizophrenia

It is demonstrated that loss of membrane-bound catechol-O-methyltransferase (MB-COMT), a key degrader of DA in the brain, disrupts cellular metal handling and redox-regulatory pathways and triggers widespread protein misfolding in schizophrenia and Parkinson’s disease.

S. Tripathi, Suwarna Chakraborty, Neil B. Wood et al. · Proceedings of the National... · 0 citations