Author

G. Taylor

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#gene editing Open access Sep 2026

Universal donor plasmids for biallelic degron-tagging in mammalian cells and organoids

A series of universal donor vectors are generated to enable biallelic integration of different degron tags using different selection strategies (FACS, drug selection) and can be fused in-frame to endogenous protein C-termini via homology-independent repair following Cas9-induced double strand breaks.

S. Ö. Pohl, Brianda Hernandez Moran, Camila Guzman Cardozo et al. · bioRxiv · 0 citations

#protein folding Open access Sep 2026

Oncogene activation mechanism determines the limits of targeted protein degradation.

This work developed orthogonal methods to increase production or enhance stability of β-catenin, an important oncoprotein and target for degrader therapeutics, and used the dTAG system to evaluate the consequences for PROTAC activity.

Evelina Gudauskaitė, Brianda Hernández-Morán, Gillian C. A. Taylor et al. · Cell Chemical Biology · 0 citations