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Review Open access Sep 2026

Targeting the GABA receptor for agricultural Pest control: from molecular mechanisms to novel NAM site inhibitors.

The ionotropic γ-aminobutyric acid receptor (GABAR) is a major inhibitory neurotransmitter receptor in the insect central nervous system and a proven target for multiple classes of insecticides. The recent discovery of the NAM binding site located at the transmembrane subunit interface has revitalized interest in this...

Zhao-Kai Yang, Yongfu Guo, Han Yan et al. · 0 citations
#protein folding Sep 2026

Design, Synthesis, and Insecticidal Activity of Novel Fluorine-Containing Pyrazole Benzamide Derivatives

A series of fluorine-containing pyrazole benzamide derivatives were designed and synthesized. Compound Z1 exhibited significantly higher activity against P. xylostella (LC50 = 0.203 mg/L) than that of ethiprole (LC50 = 2.88 mg/L). Compounds Z1, Z8, and Z20 showed over 13-fold higher activity against S. frugiperda (LC...

Wei Sun, Xin-Yi Zhang, An-Jing Liao et al. · 0 citations

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