Sep 2026· Journal of Agricultural and Food Chemistry· Vol 74, pp. 29597-29606· 0 citations· 36 references
Insect-Plant Interactions and Control
Abstract
A series of fluorine-containing pyrazole benzamide derivatives were designed and synthesized. Compound Z1 exhibited significantly higher activity against P. xylostella (LC50 = 0.203 mg/L) than that of ethiprole (LC50 = 2.88 mg/L). Compounds Z1, Z8, and Z20 showed over 13-fold higher activity against S. frugiperda (LC50 = 3.38, 2.72, and 2.18 mg/L) than ethiprole (LC50 = 53.6 mg/L). Furthermore, compounds Z1, Z4, and Z20 exhibited good activity against O. furnacalis (LC50 = 4.21, 3.20, and 3.30 mg/L, respectively), with over 7-fold higher potency than ethiprole (LC50 = 30.8 mg/L). SAR analysis indicated that smaller substituents favored the insecticidal activity. MD simulations and ELISA confirmed that Z1 and tigolaner both target GABA receptors. Transcriptomic analysis further revealed that Z1 treatment disrupted motor protein and neuroactive ligand–receptor interaction pathways, upregulated ELOVL7 and SCD to remodel membrane lipids, and activated GST-mediated detoxification. These multipathway perturbations collectively underpin the insecticidal mechanism of Z1.
Isoxazoline insecticides exhibit broad-spectrum and highly effective insecticidal activity by acting on insect GABA receptors. Existing insecticides have high toxicity towards non-target organisms, such as bees, limiting their practical use. This study utilized an active group splicing approach to create 41 new isoxa...
Zhong-Lu You, Bo-Yi Sun, Zheng-Wei Wu et al.· Journal of Agricultural and...· 0 citations
Findings suggested that compound 6m might be a potent candidate as a succinate dehydrogenase inhibitor (SDHI) against R. solani with strong protective and curative effects even at 50 μg/mL.
Bo Luo, Yan-Bing Wu, Qingsi Zhang et al.· Journal of Agricultural and...· 0 citations
BACKGROUND
Agricultural pests significantly reduce crop yields and threaten global food security. Chemical pesticides remain the primary means of pest control. In this study, celangulin V, a plant-derived insecticide, was used as a lead compound. Guided by three-dimensional quantitative structure-activity relationship...
Zi-Yu Wang, Yuan-Yuan Yang, Rong Tang et al.· Pest Management Science· 0 citations
A total of twenty pyrazole derivatives were synthesized using alkoxy or halo acetophenones in reaction with N, N-dimethylformamide dimethylacetal (DMF-DMA). These compounds were characterized through 1H NMR, 13C NMR, and LC-HRMS techniques. Their herbicidal efficacy against barnyard grass (Echinochloa crus-galli) was e...
K. Tripathi, Rakesh Kumar, P. Kaushik et al.· Applied Biochemistry and Bio...· 0 citations
A series of 30 novel α-methylene-γ-butyrolactone (MBL) derivatives were designed and synthesized. Bioassays revealed that several compounds exhibited potent fungicidal activities against Valsa mali, Rhizoctonia solani, and Phytophthora capsici. A25 showed the highest activity against V. mali (EC50 = 0.70 mg/L). Against...
Deyou Yang, Heng Li, Jiaying Xu et al.· Journal of Agricultural and...· 0 citations
To continue our research on developing PPO inhibitors, we replaced the triazinone core of compounds B, G, and H from our previous work with pyrimidinediones, employing a scaffold-hopping strategy to design and synthesize compounds I, J, and K. Compound I18 exhibited potent NtPPO inhibition (Ki = 10.9 nM) and broad-sp...
Wei Zhang, Ke-Shi Luo, Di Li et al.· Journal of Agricultural and...· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
