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Hila Ben-David

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#protein folding Open access Oct 2026

HSP60 and HSP10 depletion provoke distinct biological responses

Abstract The mitochondrial chaperone and co-chaperone HSP60/HSP10 (HSPD1/ HSPE1), the mammalian homologues of bacterial GroEL/GroES, form a barrel-and-lid complex to fold newly imported or misfolded mitochondrial proteins. Several lines of evidence suggest that HSPD1 and HSPE1 have diverged in function. HSPD1 and HSPE1...

Hila Ben-David, Shani Gabbay, Sufa Sued-Hendrickson et al. · 0 citations
#protein folding Open access Sep 2026

HSPD1 promotes neuroblastoma by augmenting MYCN expression

It is shown that HSPD1 depletion in MYCN-amplified NB cells led to reduced mitochondrial translation, MYCN expression, and tumorigenesis in vitro and in vivo and establishes HSPD1 as a promising target for the treatment of MYCN-amplified NB.

Shatha S. Alassam, Dinesh Babu Manikandan, Hila Ben-David et al. · 0 citations

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