The
APOEε4
allele is the strongest known genetic risk factor for late-onset Alzheimer disease (AD). However, the risk effect of
APOEε4
varies substantially by ancestry, with individuals of African ancestry (AF) demonstrating markedly lower risk compared to those of European ancestry (EU). This difference in r...
M. D. M. Muniz Moreno, K. Celis, F. Rajabli et al.· Frontiers in Aging Neuroscie...· 0 citations
Despite prolific genomic data from individuals with Alzheimer's disease (AD), translation into treatments has lagged. Here we applied Mendelian randomization to multiple AD genome-wide association studies and functional multiomics datasets to nominate druggable targets, identifying 19 targets for individuals of Europea...
An APOE-independent polygenic risk score for Alzheimer’s disease derived from multiancestry GWAS summary statistics shows consistent associations with cognitive, imaging, biomarker and neuropathological features in diverse populations.
N. Kurniansyah, S. Tasaki, H. Rehman et al.· Nature Genetics· 0 citations
Epigenetic aging clocks based on DNA methylation patterns across the genome have emerged as a potential biomarker for risk of age-related diseases, like Alzheimer’s disease (AD), and environmental and social stressors. However, methylation clocks have not been comprehensively validated in genetically diverse individual...
