Open access
Stratification by a polygenic risk score of common variation aids in Alzheimer's disease rare variant discovery
Oluwatosin A. Olayinka
John J. Farrell
Congcong Zhu
Z. Khurshid
Eden R. Martin
William S. Bush
M. Pericak-Vance
Li-San Wang
G. Schellenberg
J. Haines
K. Lunetta
Xiao-Ling Zhang
L. Farrer
Medicine
Abstract
We utilized an Alzheimer's disease (AD) polygenic risk score (PRS) to discover associations with novel rare variants (RVs).