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Jul 2026

Biosynthesis of Fluorinated Aromatic Polyketides Through Directed Evolution of Fused Type III Polyketide Synthase.

Aromatic polyketides have gained significant attention as prominent plant-derived polyphenol molecules in recent years owing to their multi-faceted therapeutic potentials against a variety of diseases. However, the introduction of unique fluorine atoms into the core structure of aromatic polyketides has received limite...

Ze-Long Mei, Jia-Xin Guo, Zhou-Tong Sun et al. · 0 citations
#protein folding Aug 2026

Engineering inflammation-responsive proteins through nitric oxide-caged amino acids.

This work reports a protein engineering strategy that enables selective restoration of protein function in nitric oxide-rich environments and establishes nitric oxide-triggered chemical reactivation of proteins as a generalizable method for post-translational control of protein function.

Wenkang Cai, Jun-Hao Cui, Zhiying Zeng et al. · 0 citations

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