Karim Sallam

Gut microbiome shifts in chronic systolic heart failure are associated with disease severity and clinical improvement

The contribution of the gut microbiome to chronic heart failure (HF) remains poorly defined. We performed integrated microbiome and host multi-omic profiling of adults with chronic systolic HF due to nonischemic cardiomyopathy (n = 59) and healthy participants (n = 50), including longitudinal sampling in some cases. He...

Artificial Intelligence-Enabled Detection and Management of Physiological Instability in Heart Failure: Results of the Randomized LINK-HF2 Trial.

BACKGROUND Artificial intelligence (AI)-enabled wearable monitoring can detect individualized physiological deviations preceding heart failure (HF) decompensation, but whether these signals can be translated into improved outcomes remains uncertain. OBJECTIVES This study aims to evaluate the feasibility of integratin...

RUNX1-driven endothelial-to-mesenchymal transition contributes to remodelling in LMNA cardiomyopathy.

Generation of two homozygous iPSC lines carrying variants of uncertain significance in LMNA associated with cardiomyopathy

Two isogenic induced pluripotent stem cell lines carrying homozygous LMNA variants are generated by prime editing of a healthy donor iPSC line, providing a valuable platform for functional characterization and potential clinical reclassification of LMNA VUS.