Magnesium is an essential cofactor in numerous enzymatic reactions regulating neuronal excitability, neurotransmission, and stress response. Deficiency has been linked to affective dysregulation through altered N-methyl-D-aspartate (NMDA) and γ-aminobutyric acid (GABA) signaling, impaired neuroplasticity, and activatio...
Lorenzo Campedelli, Andrea Cicoli, M. Lastretti et al.· Food Production, Processing...· 0 citations
Neuroendocrine Disruptors (NEDs) are increasingly recognized as a significant environmental and public health concern, particularly in low-resource settings where environmental contamination and inadequate waste management may increase human exposure. NEDs include a heterogeneous group of exogenous chemicals capable of...
Andrea Faa, M. Lastretti, Monica Piras et al.· Healthcare in Low-resource S...· 0 citations
BackgroundAlzheimer's disease (AD) is the most common cause of dementia, affecting over 55 million people worldwide with no established disease-modifying treatments. Lithium has emerged as a potential neuroprotective agent through multiple molecular mechanisms, and observational studies suggest reduced dementia risk am...
Lorenzo Campedelli, Andrea Cicoli, M. Lastretti et al.· Journal of Alzheimer's Disea...· 0 citations
Key mechanisms identified include Nrf2/HO-1-driven oxidative stress and neuronal apoptosis, disruption of calcium signalling and synaptic plasticity via CREB phosphorylation deficits, epigenetic suppression of brain-derived neurotrophic factor via promoter hypermethylation, interference with thyroid hormone bioavailabi...
M. Lastretti, Andrea Faa, Monica Piras et al.· Environments· 0 citations
Eotional reliance on AI represents an emerging clinical phenomenon with addiction-like features requiring specific diagnostic frameworks, evidence-based interventions, and ethical design guidelines and future research should prioritize longitudinal studies examining developmental impacts and neurobiological investigati...
M. Lastretti, M. Manchia, Matteo Fraschini et al.· Psychiatry International· 0 citations
Gut microbiota dysbiosis represents a biologically plausible mediator of depression pathophysiology, with a recurrent dysbiotic pattern, characterised by depletion of butyrate-producing taxa and enrichment of pro-inflammatory genera, showing emerging diagnostic and therapeutic potential.
Lorenzo Campedelli, Andrea Cicoli, M. Lastretti et al.· Swiss Archives of Neurology,...· 0 citations
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