Author

Manjunath B. Malshetty

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Jul 2026

Application of Proteogenomic Approaches for Refinement of the Entamoeba histolytica Reference Genome Using High Resolution Mass-Spectrometry Data

This is the first study to demonstrate proteogenomic integration of peptide-level evidence with genomic data substantially improves genome annotation in E. histolytica, expanding its known coding repertoire and providing functional insights into previously uncharacterized regions with implications for understanding par...

Manjunath B. Malshetty, Soumi Chowdhury, Shubhankar Pawar et al. · Acta Parasitologica · 0 citations

#protein folding Open access Aug 2026

In silico evaluation of deleterious nsSNPs in SOD1 and TARDBP genes associated with amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder involving mutations in the SOD1 and TARDBP genes that significantly influence its development. Nonsynonymous SNPs in these genes can disrupt protein stability, folding, and regulatory functions, leading to the loss of motor neurons....

Manjunath B. Malshetty, Sandeep Mallya, Sudharshan Prabhu · Scientific Reports · 0 citations