Application of Proteogenomic Approaches for Refinement of the Entamoeba histolytica Reference Genome Using High Resolution Mass-Spectrometry Data

TL;DR

This is the first study to demonstrate proteogenomic integration of peptide-level evidence with genomic data substantially improves genome annotation in E. histolytica, expanding its known coding repertoire and providing functional insights into previously uncharacterized regions with implications for understanding parasite biology and virulence mechanisms.